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Title: Comparison of the TaqMan and LightCycler systems in evaluation of CYP2B6 516G>T polymorphism
Authors: Soranun Chantarangsu
Tim Cressey
Surakameth Mahasirimongkol
Yardpiroon Tawon
Nicole Ngo-Giang-Huong
Gonzague Jourdain
Marc Lallemant
Wasun Chantratita
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2007
Abstract: Understanding genetically encoded inherited differences in drug metabolism and drug targets offers the promise of minimizing adverse drug reactions and improving therapies. We have compared two real-time PCR-based methods, the TaqMan®and LightCycler™ for the pharmacogenetic evaluation of CYP2B6 516G>T polymorphism. Both methods were found to be suitable for pharmacogenetic testing of CYP2B6 516G>T in the meaning of time consumption, accurate genotype calling, flexible reaction format, simple data analysis, and low cost per assay. The genotype success rate was similar, but the LightCycler procedure was less expensive in terms of cost per sample and shorter running time. © 2007 Elsevier Ltd. All rights reserved.
ISSN: 08908508
Appears in Collections:CMUL: Journal Articles

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