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Title: Neurotensin receptor 1 agonist provides neuroprotection in pre-diabetic rats
Authors: Napatsorn Saiyasit
Titikorn Chunchai
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Nattayaporn Apaijai
Wasana Pratchayasakul
Jirapas Sripetchwandee
Nipon Chattipakorn
Siriporn C. Chattipakorn
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2021
Abstract: Exogenous treatment of a neurotensin receptor 1 (NTR1) agonist exerted the neuroprotection in an obese and Alzheimer's model. However, the effects of NTR1 modulation on peripheral/hippocampal impairment and cognitive deficit following sustained HFD consumption are poorly understood. Forty rats received a normal diet (ND) or HFD for 16 weeks. At week 13, the ND group received a vehicle (n = 8). Thirty-two HFD-fed group were randomized into four subgroups (n = 8/subgroup) with a vehicle, 1 mg/kg of NTR1 agonist, 1 mg/kg of NTR antagonist, and combined treatment (NTR1 agonist-NTR antagonist) for 2 weeks, s.c. injection. Then, the cognitive tests and peripheral/hippocampal parameters were determined. Our findings demonstrated that NTR1 activator reversed obesity and attenuated metabolic impairment in pre-diabetic rats. It also alleviated hippocampal pathologies and synaptic dysplasticity, leading to deceleration or prevention of cognitive impairment progression. Therefore, NTR1 activation would be a possible novel therapy to decelerate or prevent progression of neuropathology and cognitive impairment in the pre-diabetes.
ISSN: 14796805
Appears in Collections:CMUL: Journal Articles

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