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Title: Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes
Authors: Tung Phan
Tomihiko Ide
Satoshi Komoto
Pattara Khamrin
Ngan Thi Kim Pham
Shoko Okitsu
Koki Taniguchi
Shuichi Nishimura
Niwat Maneekarn
Satoshi Hayakawa
Hiroshi Ushijima
Keywords: Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Issue Date: 1-Jan-2021
Abstract: © 2020 Elsevier B.V. Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P[8] in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P[8] strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P[8] and P[13] in the VP4 gene.
ISSN: 15677257
Appears in Collections:CMUL: Journal Articles

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