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|Title:||Genomic analysis of group A rotavirus G12P including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes|
Ngan Thi Kim Pham
|Keywords:||Agricultural and Biological Sciences|
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
|Abstract:||© 2020 Elsevier B.V. Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P and P in the VP4 gene.|
|Appears in Collections:||CMUL: Journal Articles|
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