Effects of rhizocloniumhieroglyphicum and spirogyra neglecta combined freshwater algal extract on blood glucose, lipids and oxidative markers in diabetic rats

Abstract

© 2020 by Maejo University, San Sai, Chiang Mai, 50290 Thailand. Rhizocloniumhieroglyphicum and Spirogyra neglecta are freshwater green macroalgae that exhibit antioxidant, anti-inflammatory and anti-diabetic properties. R. hieroglyphicum extract (RE) and S. neglecta extract (SE) were mixed to obtain a combined algal extract (RSE), and RSE was used as functional ingredient in an algal product (RSP). The total phenolic content of RE and SE was 8.58 and 107.02 mgGAE/g extract respectively. RSE and/or RSP, respectively, decreased glucose level by 38.53% and 41.28%, triglycerides by 2.96% and 36.84%, total cholesterol by 25.98% and 21.07% and malondialdehyde by 32.45% and 28.46% in diabetic rats but significantly increased superoxide dismutase, catalase and glutathione peroxidase activities. These findings indicate that RSE and RSP possess anti-hyperglycemic, anti-hypercholesterolemic and antioxidative stress effects.