Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities

Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388

Title:	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
Authors:	Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan
Authors:	Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan
Keywords:	Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date:	1-Jul-2020
Abstract:	© 2020 The Pharmaceutical Society of Japan. Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 μM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 μM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 μM.
URI:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087612768&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388
ISSN:	13475223 00092363
Appears in Collections:	CMUL: Journal Articles

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