Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/68426
Title: New antimicrobial phenyl alkenoic acids isolated from an oil palm rhizosphere-associated actinomycete, Streptomyces palmae CMU-AB204<sup>T</sup>
Authors: Kanaporn Sujarit
Mihoko Mori
Kazuyuki Dobashi
Kazuro Shiomi
Wasu Pathom-Aree
Saisamorn Lumyong
Keywords: Immunology and Microbiology
Medicine
Issue Date: 1-Mar-2020
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Basal stem rot (BSR), or Ganoderma rot disease, is the most serious disease associated with the oil palm plant of Southeast Asian countries. A basidiomycetous fungus, Ganoderma boninense, is the causative microbe of this disease. To control BSR in oil palm plantations, biological control agents are gaining attention as a major alternative to chemical fungicides. In the course of searching for effective actinomycetes as potential biological control agents for BSR, Streptomyces palmae CMU-AB204T was isolated from oil palm rhizosphere soil collected on the campus of Chiang Mai University. The culture broth of this strain showed significant antimicrobial activities against several bacteria and phytopathogenic fungi including G. boninense. Antifungal and antibacterial compounds were isolated by antimicrobial activity-guided purification using chromatographic methods. Their structures were elucidated by spectroscopic techniques, including Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Ultraviolet (UV), and Infrared (IR) analyses. The current study isolated new phenyl alkenoic acids 1–6 and three known compounds, anguinomycin A (7), leptomycin A (8), and actinopyrone A (9) as antimicrobial agents. Compounds 1 and 2 displayed broad antifungal activity, though they did not show antibacterial activity. Compounds 3 and 4 revealed a strong antibacterial activity against both Gram-positive and Gram-negative bacteria including the phytopathogenic strain Xanthomonas campestris pv. oryzae. Compounds 7–9 displayed antifungal activity against Ganoderma. Thus, the antifungal compounds obtained in this study may play a role in protecting oil palm plants from Ganoderma infection with the strain S. palmae CMU-AB204T.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080976291&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68426
ISSN: 20762607
Appears in Collections:CMUL: Journal Articles

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