A preliminary study on effect of lactobacillus paracasei on high-density and low-density lipoproteins level in hypercholesterolemic patients

Abstract

© 2019 IEEE. Probiotics are defined as 'live microorganisms, that when administered in suitable amounts, confer a health benefit on the host'. The evidence for the health benefits of probiotics has been increased in recent decades. Hypercholesterolemia is a major risk factor for the development of cardiovascular diseases. Several pharmacological and dietary approaches are proposed and used to reduce the cholesterol level. Though a number of drugs are currently in use to treat hypercholesterolemia, it has several undesirable side effects. The objective of the current study was to study the effect of probiotic supplementation (Lactobacillus paracasei) on high-density lipoprotein (HDL), and low-density lipoprotein (LDL) level in hypercholesterolemic patients. Seven hypercholesterolemic subjects (with an average age of 46.14 \pm 18.34 years) were supplemented with 12.5 billion cells of L. paracasei per day for 12 weeks. After 12 weeks of intervention, the changes in HDL and LDL level was calculated. Both HDL (from 61.14 \pm 9.65 to 67.29 \pm 7.99 mg/DL) and LDL (from 141.57 \pm 31.95 to 126.29 \pm 36.23 mg/DL) levels were significantly changed in the probiotic-supplemented group when compared to the baseline value. The results of the current study suggested that the supplementation of L. paracasei may help to reduce the hypercholesterolemia, and further studies are mandatory to reveal the health beneficial effect of the probiotic strain L. paracasei.