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dc.contributor.authorMattareeyapar Phaosrien_US
dc.contributor.authorSalinee Jantrapiromen_US
dc.contributor.authorMingkwan Na Takuathungen_US
dc.contributor.authorNoppamas Soonthornchareonnonen_US
dc.contributor.authorSeewaboon Sireeratawongen_US
dc.contributor.authorPensiri Buacheenen_US
dc.contributor.authorPornsiri Pitchakarnen_US
dc.contributor.authorWutigri Nimlamoolen_US
dc.contributor.authorSaranyapin Potikanonden_US
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Salacia chinensis L. (SC) stems have been used as an ingredient in Thai traditional medicine for treating patients with hepatic fibrosis and liver cirrhosis. However, there is no scientific evidence supporting the antifibrotic effects of SC extract. Therefore, this study aimed to determine the antifibrotic activity of SC stem extract in human hepatic stellate cell-line called LX-2. We found that upon TGF-β1 stimulation, LX-2 cells transformed to a myofibroblast-like phenotype with a noticeable increase in α-SMA and collagen type I production. Interestingly, cells treated with SC extract significantly suppressed α-SMA and collagen type I production and reversed the myofibroblast-like characteristics back to normal. Additionally, TGF-β1 also influenced the development of fibrogenesis by upregulation of MMP-2, TIMP-1, and TIMP-2 and related cellular signaling, such as pSmad2/3, pErk1/2, and pJNK. Surprisingly, SC possesses antifibrotic activity through the suppression of TGF-β1-mediated production of collagen type 1, α-SMA, and the phosphorylation status of Smad2/3, Erk1/2, and JNK. Taken together, the present study provides accumulated information demonstrating the antifibrotic effects of SC stem extract and revealing its potential for development for hepatic fibrosis patients.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectComputer Scienceen_US
dc.titleSalacia chinensis L. Stem extract exerts antifibrotic effects on human hepatic stellate cells through the inhibition of the tgf-β1-induced smad2/3 signaling pathwayen_US
article.title.sourcetitleInternational Journal of Molecular Sciencesen_US
article.volume20en_US Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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