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Title: Synthesis, Characterization and Antimicrobial Evaluation of Transition Metal Complexes of Monodentate 2-(Substituted Phenyl)-1H-benzo[d]imidazoles
Authors: Minaxi S Maru"
Manish K Shah
Keywords: Monodentate 1H-benzo[d]imidazole ligands
Transition metal complexes
Antimicrobial activity
Issue Date: 2015
Publisher: Science Faculty of Chiang Mai University
Citation: Chiang Mai Journal of Science 42, 1 (Jan 2015), 216 - 227
Abstract: The synthesis, spectral characterization and antimicrobial activity of copper(II) chloride, nickel(II) chloride and cobalt(II) chloride complexes of the monodentate 2-(substituted phenyl)-1H-benzo[d]imidazole ligands are represented in this research article. The complex formation of metal(II) ions were taken with 2-substituted benzimidazole ligands in 1:2 mole ratio in ethanolic solution. The ligands were derived from 3-bromo-4-hydroxy-5-methoxy benzaldehyde and 4,5-dimethoxy-2-nitro benzaldehyde. The in vitro study of antimicrobial activity of benzimidazole ligands and their metal complexes was done on bacterial strains (E. coli, P. aeruginosa, S. aureus, S. pyogenes), and fungicidal strains (C. albicans, A. niger and A. clavatus). The antimicrobial results showed that the benzimidazole complexes were more active against bacterial and fungicidal strains than their corresponding ligands. Most benzimidazole complexes were active against the bacterial strains whereas only one benzimidazole complex was active against fungicidal strains.
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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