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Title: Human Immunodeficiency Virus Type 1 and Tuberculosis Coinfection in Multinational, Resource-limited Settings: Increased neurological dysfunction
Authors: Kevin R. Robertson
Bibilola Oladeji
Hongyu Jiang
Johnstone Kumwenda
Khuanchai Supparatpinyo
Thomas B. Campbell
James Hakim
Srikanth Tripathy
Mina C. Hosseinipour
Christina M. Marra
Nagalingeswaran Kumarasamy
Scott Evans
Alyssa Vecchio
Alberto La Rosa
Breno Santos
Marcus T. Silva
Sylvia Montano
Cecilia Kanyama
Cindy Firnhaber
Richard Price
Cheryl Marcus
Baida Berzins
Reena Masih
Umesh Lalloo
Ian Sanne
Sarah Yosief
Ann Walawander
Aspara Nair
Ned Sacktor
Colin Hall
Keywords: Medicine
Issue Date: 1-May-2019
Abstract: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background. AIDS Clinical Trial Group 5199 compared neurological and neuropsychological test performance of human immunodeficiency virus type 1 (HIV-1)-infected participants in resource-limited settings treated with 3 World Health Organization-recommended antiretroviral (ART) regimens. We investigated the impact of tuberculosis (TB) on neurological and neuropsychological outcomes. Methods. Standardized neurological and neuropsychological examinations were administered every 24 weeks. Generalized estimating equation models assessed the association between TB and neurological/neuropsychological performance. Results. Characteristics of the 860 participants at baseline were as follows: 53% female, 49% African; median age, 34 years; CD4 count, 173 cells/μL; and plasma HIV-1 RNA, 5.0 log copies/mL. At baseline, there were 36 cases of pulmonary, 9 cases of extrapulmonary, and 1 case of central nervous system (CNS) TB. Over the 192 weeks of follow-up, there were 55 observations of pulmonary TB in 52 persons, 26 observations of extrapulmonary TB in 25 persons, and 3 observations of CNS TB in 2 persons. Prevalence of TB decreased with ART initiation and follow-up. Those with TB coinfection had significantly poorer performance on grooved pegboard (P < .001) and fingertapping nondominant hand (P < .01). TB was associated with diffuse CNS disease (P < .05). Furthermore, those with TB had 9.27 times (P < .001) higher odds of reporting decreased quality of life, and had 8.02 times (P = .0005) higher odds of loss of productivity. Conclusions. TB coinfection was associated with poorer neuropsychological functioning, particularly the fine motor skills, and had a substantial impact on functional ability and quality of life.
ISSN: 15376591
Appears in Collections:CMUL: Journal Articles

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