Please use this identifier to cite or link to this item:
Title: Dystrobrevin is required postsynaptically for homeostatic potentiation at the Drosophila NMJ
Authors: Salinee Jantrapirom
Wutigri Nimlamool
Piya Temviriyanukul
Somaieh Ahmadian
Cody J. Locke
Graeme W. Davis
Masamitsu Yamaguchi
Jasprina N. Noordermeer
Lee G. Fradkin
Saranyapin Potikanond
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2019
Abstract: © 2019 Elsevier B.V. Evolutionarily conserved homeostatic systems have been shown to modulate synaptic efficiency at the neuromuscular junctions of organisms. While advances have been made in identifying molecules that function presynaptically during homeostasis, limited information is currently available on how postsynaptic alterations affect presynaptic function. We previously identified a role for postsynaptic Dystrophin in the maintenance of evoked neurotransmitter release. We herein demonstrated that Dystrobrevin, a member of the Dystrophin Glycoprotein Complex, was delocalized from the postsynaptic region in the absence of Dystrophin. A newly-generated Dystrobrevin mutant showed elevated evoked neurotransmitter release, increased bouton numbers, and a readily releasable pool of synaptic vesicles without changes in the function or numbers of postsynaptic glutamate receptors. In addition, we provide evidence to show that the highly conserved Cdc42 Rho GTPase plays a key role in the postsynaptic Dystrophin/Dystrobrevin pathway for synaptic homeostasis. The present results give novel insights into the synaptic deficits underlying Duchenne Muscular Dystrophy affected by a dysfunctional Dystrophin Glycoprotein complex.
ISSN: 1879260X
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.