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http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082| Title: | New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| Authors: | Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh |
| Authors: | Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh |
| Issue Date: | 2018 |
| Publisher: | Science Faculty of Chiang Mai University |
| Abstract: | In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence. |
| URI: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8971 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082 |
| ISSN: | 0125-2526 |
| Appears in Collections: | CMUL: Journal Articles |
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