Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/62928
Title: Hypoglycemia induced by Plasmodium berghei infection is prevented by treatment with Tinospora crispa stem extract
Authors: Sakaewan Ounjaijean
Sukanya Chachiyo
Voravuth Somsak
Keywords: Immunology and Microbiology
Medicine
Issue Date: 1-Feb-2019
Abstract: © 2018 Elsevier B.V. During Plasmodium malaria parasite infection in a human, the intraerythrocytic stages lead to the clinical manifestations of the disease, especially hypoglycemia. Hypoglycemia is a recognized feature of severe malaria and linked with a high risk of mortality for children. Hence, the present study aimed to investigate the protective effect of T. crispa stem extract on hypoglycemia induced by P. berghei infection tested with a mouse model. ICR mice were inoculated with 1 × 107 parasitized erythrocytes of P. berghei ANKA (PbANKA) by intraperitoneal injection and given 50, 100, and 200 mg/kg of ethanolic extract for 4-consecutive days. The results showed that T. crispa stem extract exerted a protective effect (100%) on hypoglycemia induced by PbANKA infection at doses of 100 and 200 mg/kg. A significantly (p <.05) prolonged mean survival time (28.0 ± 1.9 days) of the extract treated mice was also observed. Additionally, no effect on blood glucose levels was seen in normal mice treated with all doses of extract. It can be concluded that T. crispa stem extract may have beneficial properties in protecting against hypoglycemia, and in increasing survival time during malaria infection.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055317110&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62928
ISSN: 18730329
13835769
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.