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Title: Triggering of CD99 on monocytes by a specific monoclonal antibody regulates T cell activation
Authors: Witida Laopajon
Supansa Pata
Nuchjira Takheaw
Sirirat Surinkaew
Saichit Khummuang
Watchara Kasinrerk
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2018
Abstract: © 2018 Elsevier Inc. CD99, a leukocyte surface glycoprotein, has been implicated in many cellular processes including cell adhesion, cell migration and T cell activation. Our previous study demonstrated the anti-CD99 monoclonal antibody (mAb) clone MT99/3 inhibited T cell activation; however, the mechanism is unclear. In this study, we demonstrated that CD99 expressed on monocytes played a role in the inhibition of T cell activation. Anti-CD99 mAb MT99/3 downregulated the expression of costimulatory molecule CD86, but upregulated IL-6, IL-10 and TNF-α production by monocytes. The inhibitory effect of mAb MT99/3 required cell to cell contact between monocytes and lymphocytes. The soluble mediators produced by monocytes alone were insufficient to induce hypo-function of T lymphocytes. In summary, we demonstrated that ligation of CD99 on monocytes by anti-CD99 mAb MT99/3 could mediate T cell hypo-responsiveness. These findings provide the first evidence of the role of CD99 on monocytes that contributes to T cell activation.
ISSN: 10902163
Appears in Collections:CMUL: Journal Articles

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