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Title: Development of suspending agent from sodium carboxymethyl mungbean starches
Authors: O. S. Kittipongpatana
J. Sirithunyalug
Keywords: Chemistry
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2006
Abstract: Three sodium carboxymethyl mungbean starches (SCMMSs) were selected, based on the physicochemical profiles and evaluated as potential pharmaceutical suspending agent in comparison with a sodium carboxymethyl tapioca starch and other five commercial suspending agents. Ibuprofen suspension was employed as a model formulation with 0.5, 1.0, and 2.0% w/v of suspending agents. Evaluation parameters included the determination of sedimentation volume ratio, redispersibility, viscosity and rheological properties and content uniformity studies. The results revealed that a high-viscosity modified mungbean starch, MMS-M-04, possessed suitable properties as a suspending agent and, at 1% concentration, was as effective as sodium carboxymethylcellulose and xanthan gum, two most-commonly used suspending agents. This modified starch could be further developed and employed as a new commercial suspending agent in the pharmaceutical industry. Copyright © Informa Healthcare.
ISSN: 15205762
Appears in Collections:CMUL: Journal Articles

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