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Title: The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
Authors: Wirote Tuntiwechapikul
Thanachai Taka
Mathilde Béthencourt
Luksana Makonkawkeyoon
T. Randall Lee
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2006
Abstract: Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity. © 2006 Elsevier Ltd. All rights reserved.
ISSN: 0960894X
Appears in Collections:CMUL: Journal Articles

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