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Title: Experience with gemcitabine and cisplatin in the therapy of inoperable and metastatic cholangiocarcinoma
Authors: Chalyut Charoentum
Sumitra Thongprasert
Busyamas Chewaskulyong
Sutthirak Munprakan
Keywords: Medicine
Issue Date: 28-May-2007
Abstract: Aim: To study the activity of gemcitabine and cisplatin in a cohort of patients with inoperable or metastatic cholangiocarcinoma. Methods: Chemotherapy-naive patients with pathologically proven cholangiocarcinoma, receiving treatment that consisted of gemcitabine at 1250 mg/m2in a 30-min infusion on d 1 and 8, and cisplatin at 75 mg/m2at every 21-d cycle, were retrospectively analyzed. Results: From June 2003 to December 2005, 42 patients were evaluated. Twelve patients (28%) had unresectable disease and 30 (72%) had metastatic disease. There were 28 males and 14 females with a median age of 51 years (range 33-67) and median ECOG PS of 1 (range 0-2). A total of 171 cycles were given with a median number of cycles of 4 (range 1-6). There were 0 CR, 9 PR, 11 SD and 13 PD (response rate 21%). Grade 3-4 hematologic toxicities were: anemia in 33%, neutropenia in 22% and thrombocytopenia in 5%. Non-hematologic toxicity was generally mild. No cases of febrile neutropenia or treatment-related death were noted. The median survival was 10.8 mo (range 8.4-13 mo) and progression free survival was 8.5 mo. One-year survival rate was 40%. Conclusion: Our results indicate that the combination of gemcitabine and cisplatin had consistent efficacy in patients with unresectable or metastatic cholangiocarcinoma. © 2007 The WJG Press. All rights reserved.
ISSN: 10079327
Appears in Collections:CMUL: Journal Articles

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