Please use this identifier to cite or link to this item:
Title: Quercetin, Siamois 1 and Siamois 2 induce apoptosis in human breast cancer MDA-MB-435 cells xenograft in vivo
Authors: Samarn Dechsupa
Suchart Kothan
Jackie Vergote
Gerard Leger
Antoine Martineau
Simone Beranger
Rachain Kosanlavit
Jean Luc Moretti
Samlee Mankhetkorn
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2007
Abstract: We sought to investigate the apoptosis-inducing activities of quercetin, Siamois 1, and Siamois 2 against invasive estrogen-receptor negative MDA-MB 435 cells xenografted in athymic nude mice. This study clearly demonstrated that these compounds exhibited apoptosis-inducing activities in cell culture system. Quercetin (20 μg/mL), Siamois 1 (100 μg/mL), and Siamois 2 (200 μg/mL) can induce apoptotic cell death by 40 ± 5%, 44 ± 14 %, and 31 ± 13 %, respectively. Two-fold of IC50of these compounds were clearly found to induce apoptosis in breast tumor tissue which can be determined by99mTc-Annexin V scintigraphy and histological staining. This is the first report that the apoptosis-inducing effects of quercetin, Siamois 1 and Siamois 2 on the MDA-MB 435 cell in vitro were effectively extrapolated to the in vivo situation. These compounds might be considered as a simple dietary supplement and with further clinical investigation for their use as a nutrition-based intervention in breast cancer treatment. ©2007 Landes Bioscience.
ISSN: 15558576
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.