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|Title:||Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters|
|Authors:||Yih Shyan Lin|
Feng Ming An
Der Zen Liu
Shui Tein Chen
|Keywords:||Biochemistry, Genetics and Molecular Biology|
Pharmacology, Toxicology and Pharmaceutics
|Abstract:||This report describes the synthesis of four novel paclitaxel based prodrugs with glycan conjugation (1-4). Glycans were conjugated using an ester or ether bond as the linker between 2′-paclitaxel and the 2′-glucose or glucuronic acid moiety. These prodrugs showed good water solubility and selective cytotoxicity against cancer cell lines, but showed reduced toxicity toward normal cell lines and cancer cell lines with low expression levels of GLUTs. The ester conjugated prodrug 1 showed the most cytotoxicity among the prodrugs examined and could be transported into cells via GLUTs. Fluorescent and confocal microscopy demonstrated that targeted cells exhibited morphological changes in tubulin and chromosomal alterations that were similar to those observed with paclitaxel treatment. Therefore, these glycan-based prodrugs may be good drug candidates for cancer therapy, and the glycan conjugation approach is an alternative method to enhance the targeted delivery of other drugs to cancer cells that overexpress GLUTs. © 2008 American Chemical Society.|
|Appears in Collections:||CMUL: Journal Articles|
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