Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/59642
Title: A new HCV genotype 6 subtype designated 6v was confirmed with three complete genome sequences
Authors: Yizhong Wang
Xueshan Xia
Chunhua Li
Niwat Maneekarn
Wenjie Xia
Wenhua Zhao
Yue Feng
Hsiang Fu Kung
Yongshui Fu
Ling Lu
Keywords: Immunology and Microbiology
Medicine
Issue Date: 1-Mar-2009
Abstract: Background: Although hepatitis C virus (HCV) genotype 6 is classified into 21 subtypes, 6a-6u, new variants continue to be identified. Objective: To characterize the full-length genomes of three novel HCV genotype 6 variants: KMN02, KM046 and KM181. Study design: From sera of patients with HCV infection, the entire HCV genome was amplified by RT-PCR followed by direct DNA sequencing and phylogenetic analysis. Results: The sera contained HCV genomes of 9461, 9429, and 9461 nt in length, and each harboured a single ORF of 9051 nt. The genomes showed 95.3-98.1% nucleotide similarity to each other and 72.2-75.4% similarity to 23 genotype 6 reference sequences, which represent subtypes 6a-6u and unassigned variants km41 and gz52557. Phylogenetic analyses demonstrated that they were genotype 6, but were subtypically distinct. Based on the current criteria of HCV classification, they were designed to represent a new subtype, 6v. Analysis of E1 and NS5B region partial sequences revealed two additional related variants, CMBD-14 and CMBD-86 that had been previously reported in northern Thailand and sequences dropped into Genbank. Conclusion: Three novel HCV genotype 6 variants were entirely sequenced and designated subtype 6v. © 2009 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=60749124401&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59642
ISSN: 13866532
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.