Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58966
Title: In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
Authors: Chattida Wiya
Kanokporn Saenphet
Supap Saenphet
Wararut Buncharoen
Authors: Chattida Wiya
Kanokporn Saenphet
Supap Saenphet
Wararut Buncharoen
Keywords: Medicine
Issue Date: 1-Mar-2018
Abstract: © 2017, Springer-Verlag London Ltd., part of Springer Nature. Irritable bowel syndrome (IBS) is a symptom of functional gastrointestinal disorders. It is commonly experienced as abdominal cramp, diarrhea, and constipation. The diagnosis and treatment of IBS were mostly conducted by synthetic medicines including antispasmodic drugs that have many side effects and are so expensive. The aim of the present study was to explore the antispasmodic activity of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair extracts on isolated rats’ ilia which later compared to atropine as reference drug. The ethanolic extracts from the stem of A. dulcis and U. rufa were investigated for their antispasmodic activities against acetylcholine-induced rats’ ilia contraction in vitro experiment. The results of this study showed that both ethanolic extracts of U. rufa and A. dulcis have an antispasmodic efficiency at all concentrations of 200, 300, 400, and 500 μg/ml on excised rats’ ilia. They produced the highest relaxation of 92.71 ± 5.97 and 98.53 ± 0.61% in A. dulcis and U. rufa extracts, respectively, while atropine produced 112.84 ± 5.61% at concentration of 10.0 μg/ml. These results suggest that U. rufa and A. dulcis could be used as antispasmodic agents for IBS treatment.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033477467&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58966
ISSN: 1618565X
16185641
Appears in Collections:CMUL: Journal Articles

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