Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58310
Title: Complex Interaction of Hb Q-Thailand (HBA1: c.223G>C) with β-Thalassemia/Hb E (HBB: c.79G>A) Disease
Authors: Sitthichai Panyasai
Surada Satthakarn
Sakorn Pornprasert
Keywords: Biochemistry, Genetics and Molecular Biology
Medicine
Issue Date: 2-Jan-2018
Abstract: © 2018 Informa UK Limited, trading as Taylor & Francis Group. Hb Q-Thailand [α74(EF3)Asp→His (α1), GAC>CAC, HBA1: c.223G>C] is an abnormal hemoglobin (Hb) frequently found in Thailand and Southeast Asian countries. The association of the αQ-Thailandallele with other globin gene disorders has important implications in diagnosis. Here, we report how to diagnose the coinheritance of Hb Q-Thailand with β-thalassemia (β-thal)/Hb E disease in four Thai samples from high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) testing results. Understanding of the HPLC chromatogram and CE electropherogram patterns of this complex mutation is important for interpretation of testing results and providing genetic counseling.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042919270&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58310
ISSN: 1532432X
03630269
Appears in Collections:CMUL: Journal Articles

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