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Title: Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib
Authors: Pongpol Thanuphol
Yukihiro Asami
Kazuro Shiomi
Ariyaphong Wongnoppavich
Patoomratana Tuchinda
Noppamas Soonthornchareonnon
Keywords: Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Issue Date: 18-Jul-2018
Abstract: © 2017, 2017 Informa UK Limited, trading as Taylor & Francis Group. The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC50values of 14.87 and 15.18M against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC50values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively.
ISSN: 14786427
Appears in Collections:CMUL: Journal Articles

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