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Title: Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial
Authors: Susan H. Eshleman
Sarah E. Hudelson
Andrew D. Redd
Ronald Swanstrom
San San Ou
Xinyi Cindy Zhang
Li Hua Ping
Estelle Piwowar-Manning
Stephen F. Porcella
Matthew F. Sievers
Craig A. Martens
Daniel Bruno
Elena Dukhovlinova
Marybeth McCauley
Theresa Gamble
Jessica M. Fogel
Devin Sabin
Thomas C. Quinn
Laurence Gunde
Madalitso Maliwichi
Nehemiah Nhando
Victor Akelo
Sikhulile Moyo
Ravindre Panchia
Nagalingeswaran Kumarasamy
Nuntisa Chotirosniramit
Marineide Gonçalves De Melo
Jose Pilotto
Beatriz Grinsztejn
Kenneth Mayer
Ying Q. Chen
James P. Hughes
Myron S. Cohen
Keywords: Medicine
Issue Date: 1-Jan-2017
Abstract: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
ISSN: 10779450
Appears in Collections:CMUL: Journal Articles

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