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Title: A randomized controlled study of intravenous fluid in acute ischemic stroke
Authors: Nijasri C. Suwanwela
Aurauma Chutinet
Seangduan Mayotarn
Ratchayut Thanapiyachaikul
Napasri Chaisinanunkul
Thanin Asawavichienjinda
Sombat Muengtaweepongsa
Yongchai Nilanont
Jitlada Samajarn
Kanokwan Watcharasaksilp
Somsak Tiamkao
Pakkawan Vongvasinkul
Supparat Charnwut
Jeffrey L. Saver
Keywords: Medicine
Issue Date: 1-Oct-2017
Abstract: © 2017 Elsevier B.V. Objective To compare the outcome of patients with acute ischemic stroke who received or did not receive intravenous fluid. Patients and methods This study was a prospective, multicenter, randomized, open-label trial with blinded outcome assessment. We enrolled acute ischemic stroke patients without dehydration aged between 18 and 85 years with NIH Stroke Scale score (NIHSS) score from 1 to 18 who presented within 72 h after onset. Patients were randomly assigned to receive 0.9% NaCl solution 100 ml/h for 3 days or no intravenous fluid. Results On the interim unblinded analysis of the safety data, significant excess early neurological deterioration was observed among patients in the non-intravenous fluid group. Therefore, the study was prematurely discontinued after enrollment of 120 patients, mean age 60 years, 56.6% male. Early neurological deterioration (increased NIHSS ≥3 over 72 h) not of metabolic or hemorrhagic origin was observed in 15% of the non-IV fluid group and 3.3% of the IV fluid group (p = 0.02). Predictors of neurological deterioration were higher NIHSS score, higher plasma glucose, and increased pulse rate. There was no difference in the primary efficacy outcome, NIHSS ≤ 4 at day 7, 83.3% vs 86.7%, p = 0.61 or secondary efficacy outcomes. Conclusion Administration of 0.9% NaCl 100 ml/h for 72 h in patients with acute ischemic stroke is safe and may be associated with a reduced risk of neurological deterioration. These study findings support the use of intravenous fluid in acute ischemic stroke patients with NIHSS less than 18 who have no contraindications.
ISSN: 18726968
Appears in Collections:CMUL: Journal Articles

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