Ph<inf>3</inf>P/I<inf>2</inf>-Mediated Synthesis of 3-Aryl-Substituted and 3,4-Disubstituted Coumarins

Abstract

© Georg Thieme Verlag Stuttgart New York. Ph3P/I2-Et3N-mediated one-pot two-step esterification-cyclization toward 3-aryl coumarins and 3-aryl-4-methylcoumarins is reported. The reaction of a variety of aryl acetic acids containing steric or reactive group with 2-hydroxybenzaldehydes or 2′-hydroxyacetophenone proceeded smoothly at room temperature to afford the corresponding products in good to excellent yields using inexpensive and readily available reactants and reagents.