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|Title:||Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots|
Thunwadee Limtharakul (née Ritthiwigrom)
Stephen G. Pyne
|Keywords:||Agricultural and Biological Sciences|
Biochemistry, Genetics and Molecular Biology
|Abstract:||© 2017 Informa UK Limited, trading as Taylor & Francis Group The phytochemical investigation of an alkaloidal extract of Holarrhena pubescens roots led to the isolation and identification of a new pregnene-type alkaloid, mokluangin D (1), together with nine known steroidal alkaloids (2–10). The structure of the new metabolite was determined on the basis of spectroscopic analyses including 1D- and 2D-NMR spectroscopy and mass spectrometry. Compounds 3 and 4 showed potent antimalarial activity against Plasmodium falciparum K1 stain with IC50values of 1.2 and 2.0 μM, respectively, and showed weak cytotoxic activity against the NCI-H187 cell line with IC50values of 27.7 and 30.6 μM, respectively. The substituent groups at C-3 and the carbonyl group at C-18 are important for the activity against the P. falciparum K1 stain.|
|Appears in Collections:||CMUL: Journal Articles|
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