Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56252
Title: Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database
Authors: Jin Young Ahn
David Boettiger
Sasisopin Kiertiburanakul
Tuti Parwati Merati
Bui Vu Huy
Wing Wai Wong
Rossana Ditangco
Man Po Lee
Shinichi Oka
Nicolas Durier
Jun Yong Choi
C. V. Mean
V. Saphonn
K. Vohith
F. J. Zhang
H. X. Zhao
N. Han
M. P. Lee
P. C.K. Li
W. Lam
Y. T. Chan
N. Kumarasamy
S. Saghayam
C. Ezhilarasi
S. Pujari
K. Joshi
S. Gaikwad
A. Chitalikar
D. N. Wirawan
F. Yuliana
E. Yunihastuti
D. Imran
A. Widhani
S. Oka
J. Tanuma
T. Nishijima
J. Y. Choi
S. Na
J. M. Kim
B. L.H. Sim
Y. M. Gani
R. David
A. Kamarulzaman
S. F. Syed Omar
S. Ponnampalavanar
I. Azwa
R. Ditangco
E. Uy
R. Bantique
W. W. Wong
W. W. Ku
P. C. Wu
O. T. Ng
P. L. Lim
L. S. Lee
P. S. Ohnmar
P. Phanuphak
K. Ruxrungtham
A. Avihingsanon
P. Chusut
S. Sirivichayakul
S. Sungkanuparph
L. Chumla
N. Sanmeema
R. Chaiwarith
T. Sirisanthana
W. Kotarathititum
J. Praparattanapan
P. Kantipong
P. Kambua
W. Ratanasuwan
R. Sriondee
V. K. Nguyen
V. H. Bui
T. H.D. Nguyen
T. D. Nguyen
T. T. Pham
D. D. Cuong
H. L. Ha
A. H. Sohn
N. Durier
B. Petersen
D. A. Cooper
M. G. Law
A. Jiamsakul
D. C. Boettiger
Keywords: Medicine
Issue Date: 1-Jan-2016
Abstract: Copyright © 2016 Ahn JY et al; licensee International AIDS Society. Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015897781&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56252
ISSN: 17582652
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.