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Title: Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings
Authors: Jessica F. Magidson
Xin Li
Matthew J. Mimiaga
Ayana T. Moore
Kriengkrai Srithanaviboonchai
Ruth Khalili Friedman
Mohammad Limbada
James P. Hughes
Vanessa Cummings
Charlotte A. Gaydos
Vanessa Elharrar
David Celentano
Kenneth H. Mayer
Steven A. Safren
Keywords: Medicine
Issue Date: 1-Apr-2016
Abstract: © 2015, Springer Science+Business Media New York. Successful biomedical prevention/treatment-as-prevention (TasP) requires identifying individuals at greatest risk for transmitting HIV, including those with antiretroviral therapy (ART) nonadherence and/or ‘amplified HIV transmission risk,’ defined as condomless sex with HIV-uninfected/unknown-status partners when infectious (i.e., with detectable viremia or STI diagnosis according to Swiss criteria for infectiousness). This study recruited sexually-active, HIV-infected patients in Brazil, Thailand, and Zambia to examine correlates of ART nonadherence and ‘amplified HIV transmission risk’. Lower alcohol use (OR = .71, p < .01) and higher health-related quality of life (OR = 1.10, p < .01) were associated with greater odds of ART adherence over and above region. Of those with viral load data available (in Brazil and Thailand only), 40 % met Swiss criteria for infectiousness, and 29 % had ‘amplified HIV transmission risk.’ MSM had almost three-fold (OR = 2.89, p < .001) increased odds of ‘amplified HIV transmission risk’ (vs. heterosexual men) over and above region. TasP efforts should consider psychosocial and contextual needs, particularly among MSM with detectable viremia.
ISSN: 15733254
Appears in Collections:CMUL: Journal Articles

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