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|Title:||Ph<inf>3</inf>P/I<inf>2</inf>-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines|
|Keywords:||Biochemistry, Genetics and Molecular Biology|
Pharmacology, Toxicology and Pharmaceutics
|Abstract:||© 2016 Elsevier Ltd A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidines in good to excellent yields under mild conditions.|
|Appears in Collections:||CMUL: Journal Articles|
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