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Title: Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review
Authors: Myung Ju Ahn
Anil D'Cruz
Jan B. Vermorken
Jo Pai Chen
Imjai Chitapanarux
Huy Quoc Thinh Dang
Alex Guminski
Danita Kannarunimit
Tong Yu Lin
Wai Tong Ng
Keon Uk Park
Anthony Tak Cheung Chan
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Feb-2016
Abstract: © 2015 The Authors. Published by Elsevier Ltd. Toxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much concern. There is a lack of clinical criteria for defining these patient populations, which has posed serious problems associated with increased morbidity and consequently an adverse effect on patients' quality of life. In addition, there is a lack of consensus on clinical criteria for defining such patient populations, who may be unsuitable for concurrent chemoradiotherapy. A group of experts in the field of head and neck cancer from the Asia Pacific Region convened in August 2014 in Korea to discuss the development of a set of clinical criteria in order to fill the knowledge gap and provide a reference tool for head and neck oncologists. This paper reports the final output from this meeting and the accompanying literature review, with the aim of aiding clinical decision making with the help of some clinical criteria to identify platinum unsuitable patient populations in head and neck cancer management. Some alternative treatment options are also discussed in this paper.
ISSN: 18790593
Appears in Collections:CMUL: Journal Articles

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