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Title: Development of a tablet form of liu wei di huang extract
Authors: Vorawut Jearasakulpol
Pramote Tipduangta
Supanimit Teekachunhatean
Natthakarn Chiranthanut
Sunee Chansakaow
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2015
Abstract: © 2015, International Journal of Pharmacy and Pharmaceutical Science. All right resurved. Objective: Develop an effective and stable tablet form of Liu Wei Di Huang (LWDH). Methods: LWDH extract was obtained by decoction (TC) and reflux with water (WR). Extracts were concentrated and analyzed by HPLC-PDA using loganin as the bioactive marker. Adsorbents, tablet strength and friability, and tablet quality and stability were evaluated. Results: Extraction of LWDH formula from raw materials using WR yielded higher concentrations of loganin than TC. The best formulation of LWDH tablets included Avicel®PH101, corn starch, purified talcum, magnesium stearate and Cab-osil® Conclusion: Extraction of LWDH formula using reflux with water produces higher yields than decoction. A suitable tablet formulation consists of dried water extract (38.83 %), corn starch (29.13 %), Avicel with about 97.40 % of the label amount of active marker. Excluding moisture from the product reduced marker degradation, suggesting a product shelf life 12+months. Finished tablets were uniform in weight, friability, disintegrated in<30 min, had good microbial and heavy metal contamination safety profiles and was stable. ®PH101 (29.13 %), purified talcum (0.97 %), magnesium stearate (0.97 %) and Cab-osil® (0.97 %) prepared by wet granulation. Excluding moisture from the product reduces product degradation, suggesting a shelf life of 12+months. LWDH tablets avoid traditional formulation problems (high dosages, unacceptable taste and odor, lack of product uniformity, contamination with microorganisms and heavy metals), and are a good alternative for patients and TCM practitioners.
ISSN: 09751491
Appears in Collections:CMUL: Journal Articles

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