Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/54836
Title: Current and future treatment strategies for iron overload cardiomyopathy
Authors: Suwakon Wongjaikam
Sirinart Kumfu
Siriporn C. Chattipakorn
Suthat Fucharoen
Nipon Chattipakorn
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Oct-2015
Abstract: © 2015 Elsevier B.V. All rights reserved. Iron overload cardiomyopathy is the major cause of death in transfusion-dependent thalassemia (TDT) patients. Growing evidence demonstrates that combined iron chelators, or the combination of an iron chelator with antioxidant(s) are effective in diminishing myocardial iron deposition and attenuating cardiac dysfunction. This review comprehensively summarizes basic and clinical reports on the therapeutic efficacy of combined iron chelators, or the combination of an iron chelator with antioxidant(s) on the heart. Promising benefits of these treatments in preventing cardiac dysfunction due to iron overload could provide extensive insight into future therapeutic strategies for better treatment and prevention of cardiomyopathy in TDT patients.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940040361&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/54836
ISSN: 18790712
00142999
Appears in Collections:CMUL: Journal Articles

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