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Title: Pharmacokinetic interactions between quinine and lopinavir/ritonavir in healthy Thai adults
Authors: Siwalee Rattanapunya
Tim R. Cressey
Ronnatrai Rueangweerayut
Yardpiroon Tawon
Panida Kongjam
Kesara Na-Bangchang
Keywords: Immunology and Microbiology
Issue Date: 1-Dec-2015
Abstract: © 2015 by The American Society of Tropical Medicine and Hygiene. This study aimed to investigate the pharmacokinetic interactions between quinine and lopinavir boosted with ritonavir (LPV/r) in healthy Thai adults (8 males and 12 females). Period 1 (day 1): subjects received a single oral dose of 600 mg quinine sulfate. Period 2: subjects received LPV/r (400/100 mg) twice daily. Period 3: subjects received a single quinine sulfate dose plus LPV/r twice a day. Intensive blood sampling was performed during each phase. Quinine AUC0-48h(area under the plasma concentration-time curve from time 0 to 48 hours), AUC0-∞(area under the plasma concentration-time curve from time 0 to infinity), and Cmax(maximum concentration over the time-span specified), were 56%, 57%, and 47% lower, respectively, in the presence of LPV/r. 3-Hydroxyquinine AUC0-48h, AUC0-∞, and Cmaxwere significantly lower and the metabolite-to-parent ratio was significantly reduced. Lopinavir and ritonavir exposures were not significantly reduced with quinine coadministration, but Cmaxof both drugs were significantly lower. The geometric mean ratio (GMR) and 90% CI of AUC0-48h, AUC0-∞and Cmaxfor quinine, 3-hydroxyquinine, lopinavir, and ritonavir lay outside the bioequivalent range of 0.8-1.25. Drug treatments during all periods were generally well tolerated. The reduction in systemic exposure of quinine and 3-hydroxyquinine with concomitant LPV/r use raises concerns of suboptimal exposure. Studies in HIV/malaria coinfection patients are needed to determine the clinical impact to decide if any change to the quinine dose is warranted.
ISSN: 00029637
Appears in Collections:CMUL: Journal Articles

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