Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/54119
Title: Vaccination for 2009 pandemic H1N1 influenza A did not induce conserved epitope-specific memory CD8 T cell responses in HIV+ northern Thai children
Authors: Kriangkrai Chawansuntati
Linda Aurpibul
Jiraprapa Wipasa
Keywords: Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Medicine
Veterinary
Issue Date: 11-Sep-2015
Abstract: © 2015 Elsevier Ltd. The influenza virus causes severe illness in susceptible populations, including children and people living with human immunodeficiency virus (HIV). Here, we investigated cell-mediated immune responses (CMI) against influenza CD8 T cell conserved epitopes in HIV-infected (HIV+) northern Thai children following the 2009 pandemic H1N1 influenza A vaccination. Sixty HIV+ children were vaccinated with two doses of the 2009 pandemic influenza vaccine and their CD8. T cell responses were assessed. We found no significant differences in the increase of cytokines-producing and CD107a-expressing CD8+ T cells or CD8+ memory T cells in response to pooled conserved epitopes stimulation in vitro between children with different serologic responses to the vaccine at all time points of the study. Our results suggest that the 2009 pandemic H1N1 vaccine did not induce the conserved epitope-specific immune responses in HIV+ children. Vaccine design and vaccination strategy against influenza in these populations warrant further studies.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940721755&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/54119
ISSN: 18732518
0264410X
Appears in Collections:CMUL: Journal Articles

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