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http://cmuir.cmu.ac.th/jspui/handle/6653943832/54096| Title: | TCT-mediated synthesis of N-acylbenzotriazoles in aqueous media |
| Authors: | Sirawit Wet-Osot Wong Phakhodee Mookda Pattarawarapan |
| Authors: | Sirawit Wet-Osot Wong Phakhodee Mookda Pattarawarapan |
| Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 16-Dec-2015 |
| Abstract: | © 2015 Elsevier Ltd. All rights reserved. The synthesis of N-acylbenzotriazoles has been demonstrated by the 2,4,6-trichloro-1,3,5-triazine (TCT)-mediated condensation of carboxylic acids with 1H-benzotriazole in aqueous media. In saturated aqueous sodium bicarbonate, TCT was found to be relatively stable and functioned as an efficient acid activator in the acyl transfer process. This operationally simple and economic method allows the scalable synthesis of N-acylbenzotriazoles in good to excellent yields. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84947599657&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54096 |
| ISSN: | 18733581 00404039 |
| Appears in Collections: | CMUL: Journal Articles |
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