Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/53923
Title: Clinical study on the effects of diacerein and diacerein combined with chondroitin sulfate on canine hip osteoarthritis
Authors: Korakot Nganvongpanit
Burin Boonsri
Thatdanai Sripratak
Patsanan Markmee
Prachya Kongtawelert
Keywords: Veterinary
Issue Date: 1-May-2014
Abstract: This study aimed to evaluate the effects of diacerein (DAR) and DAR combined with chondroitin sulfate (CS) for treatment of canine hip osteoarthritis (OA) in a 6-month clinical trial. Client-owned dogs included in the study consisted of 27 males and 25 females, aged 59.43±17.05 months old and weighing 17.63±5.19 kg. The dogs were randomly divided into five groups: DAR50 (administration of DAR 50 mg daily); DAR100 (DAR 100 mg daily); DAR50/CS (DAR 50 mg + CS 525 mg daily); DAR100/CS (DAR 100 mg + CS 525 mg daily); and CS (CS 525 mg daily). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical scores and radiographic findings. Blood samples were collected three times (pre-treatment, and after 3 and 6 months) for evaluation of the serum biomarker, CS-WF6. Dogs treated with DAR showed statistically significant improvements (P<0.05) in lameness, joint mobility, pain on palpation, weight-bearing, and overall clinical score at 3, 6, 5, 4, and 4 months, respectively, after the start of treatment. Side effects, including diarrhea and dark-colored urine, were found in all groups receiving DAR. After the 3rd month, the level of serum CS-WF6 in the CS group was significantly elevated (P<0.05), while the other four groups showed a significant decrease (P<0.05). The results showed that DAR 50 or 100 mg had a similarly positive therapeutic effect on dogs with osteoarthritis. The use of DAR alone or in combination with CS resulted in decreased degradation of OA cartilage.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897609012&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53923
ISSN: 13006045
Appears in Collections:CMUL: Journal Articles

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