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|Title:||Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database|
Chau V. Do
Lam Van Nguyen
Khanh Huu Truong
Nik Khairulddin Nik Yusoff
Kamarul Azahar Razali
Moy Siew Fong
Dewi Kumara Wati
|Abstract:||Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings. © 2014 by Lippincott Williams & Wilkins.|
|Appears in Collections:||CMUL: Journal Articles|
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