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Title: Molecular characterization and sequence analysis of the 2B region of Aichivirus C strains in Japan and Thailand
Authors: Shoko Okitsu
Pattara Khamrin
Aksara Thongprachum
Angela F.C. Kalesaran
Sayaka Takanashi
Hiroyuki Shimizu
Niwat Maneekarn
Masashi Mizuguchi
Satoshi Hayakawa
Hiroshi Ushijima
Keywords: Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Issue Date: 1-Jan-2014
Abstract: Aichivirus C is the third species in the genus Kobuvirus, family Picornaviridae, and the virus is circulating in pigs worldwide. Aichivirus A in humans and Aichivirus B in cows have been shown to associate with diarrheal diseases, however, the pathogenesis of Aichivirus C has not been demonstrated clearly. In this study, the full genome nucleotide sequence of the Thai strain, CMP06/2007/THA collected from stool sample of a diarrheal piglet was analyzed and identified as a variant type with a 90-nt deletion in the 2B-coding region. In addition, molecular characterization of nucleotide sequences of the 2B-coding region of Aichivirus C strains from six diarrheal and six healthy piglets in Thailand, and four strains from healthy pigs in Japan revealed that all of the strains in this study were variant types. These findings indicate that variant strains of Aichivirus C are circulating in Asian countries such as China, Thailand and Japan, and deletion of tandem repeat of 2B-region is unlikely to associate with the pathogenesis of the virus. © 2014 Elsevier B.V.
ISSN: 15677257
Appears in Collections:CMUL: Journal Articles

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