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Title: Renal biomarkers predict nephrotoxicity after paraquat
Authors: Klintean Wunnapuk
Xin Liu
Philip Peake
Glenda Gobe
Zoltan Endre
Jeffrey E. Grice
Michael S. Roberts
Nicholas A. Buckley
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 9-Oct-2013
Abstract: Paraquat is a widely used herbicide which has been involved in many accidental and intentional deaths. Nephrotoxicity is common in severe acute paraquat poisoning. We examined seven renal injury biomarkers, including cystatin-C, kidney injury molecule-1, β2-microglobulin, clusterin, albumin, neutrophil gelatinase-associated lipocalin and osteopontin, to develop a non-invasive method to detect early renal damage and dysfunction and to compare with the conventional endogenous marker creatinine. Male Wistar rats were dosed orally with four different doses of paraquat, and the biomarker patterns in urine and plasma were investigated at 8, 24 and 48h after paraquat exposure. By Receiver Operating Characteristic analysis, urinary kidney injury molecule-1 was the best marker at predicting histological changes, with areas under the Receiver Operating Characteristic curve of 0.81 and 0.98 at 8 and 24h (best cut-off value>0.000326μg/ml), respectively. Urinary kidney injury molecule-1, urinary albumin and urinary Cystatin-C elevations correlated with the degree of renal damage and injury development. Further study is required to compare biomarkers changes in rats with those seen in human poisoning. © 2013 Elsevier Ireland Ltd.
ISSN: 18793169
Appears in Collections:CMUL: Journal Articles

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