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Title: Undisclosed antiretroviral drug use in a multinational clinical trial (HIV prevention trials network 052)
Authors: Jessica M. Fogel
Lei Wang
Teresa L. Parsons
San San Ou
Estelle Piwowar-Manning
Ying Chen
Victor O. Mudhune
Mina C. Hosseinipour
Johnstone Kumwenda
James G. Hakim
Suwat Chariyalertsak
Ravindre Panchia
Ian Sanne
Nagalingeswaran Kumarasamy
Beatriz Grinsztejn
Joseph Makhema
Jose Pilotto
Breno R. Santos
Kenneth H. Mayer
Marybeth McCauley
Theresa Gamble
Namandjé N. Bumpus
Craig W. Hendrix
Myron S. Cohen
Susan H. Eshleman
Keywords: Medicine
Issue Date: 15-Nov-2013
Abstract: The HIV Prevention Trials Network 052 study enrolled serodiscordant couples. Index participants infected with human immunodeficiency virus reported no prior antiretroviral (ARV) treatment at enrollment. ARV drug testing was performed retrospectively using enrollment samples from a subset of index participants. ARV drugs were detected in 45 of 96 participants (46.9%) with an undetectable viral load, 2 of 48 (4.2%) with a low viral load, and 1 of 65 (1.5%) with a high viral load (P < .0001); they were also detected in follow-up samples from participants who were not receiving study-administered treatment. ARV drug testing may be useful in addition to selfreport of ARV drug use in some clinical trial settings. © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:CMUL: Journal Articles

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