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Title: Serial echocardiographic left ventricular ejection fraction measurements: A tool for detecting thalassemia major patients at risk of cardiac death
Authors: Aurelio Maggio
Angela Vitrano
Giuseppina Calvaruso
Rita Barone
Paolo Rigano
Luigi Mancuso
Liana Cuccia
Marcello Capra
Lorella Pitrolo
Luciano Prossomariti
Aldo Filosa
Vincenzo Caruso
Calogera Gerardi
Saveria Campisi
Paolo Cianciulli
Androulla Elefteriou
Michel Angastiniotis
Hala Hamza
Paul Telfer
John Malcolm Walker
Arintaya Phrommintikul
Nipon Chattipakorn
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Apr-2013
Abstract: Cardiac damage remains a major cause of mortality among patients with thalassemia major. The detection of a lower cardiac magnetic resonance T2* (CMR-T2*) signal has been suggested as a powerful predictor of the subsequent development of heart failure. However, the lack of worldwide availability of CMR-T2* facilities prevents its widespread use for follow-up evaluations of cardiac function in thalassemia major patients, warranting the need to assess the utility of other possible procedures. In this setting, the determination of left ventricular ejection fraction (LVEF) offers an accurate and reproducible method for heart function evaluation. These findings suggest a reduction in LVEF ≥ 7%, over time, determined by 2-D echocardiography, may be considered a strong predictive tool for the detection of thalassemia major patients with increased risk of cardiac death. The reduction of LVEF ≥ 7% had higher (84.76%) predictive value. Finally, Kaplan-Meier survival curves of thalassemia major patients with LVEF ≥ 7% showed a statistically significant decreased probability of survival for heart disease (p = 0.0022). However, because of limitations related to the study design, such findings should be confirmed in a large long-term prospective clinical trial. © 2012 Elsevier Inc.
ISSN: 10960961
Appears in Collections:CMUL: Journal Articles

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