Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51846
Title: Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men
Authors: Peter L. Anderson
David V. Glidden
Albert Liu
Susan Buchbinder
Javier R. Lama
Juan Vicente Guanira
Vanessa McMahan
Lane R. Bushman
Martín Casapía
Orlando Montoya-Herrera
Valdilea G. Veloso
Kenneth H. Mayer
Suwat Chariyalertsak
Mauro Schechter
Linda Gail Bekker
Esper Georges Kallás
Robert M. Grant
Keywords: Medicine
Issue Date: 12-Sep-2012
Abstract: Drug concentrations associated with protection from HIV-1 acquisition have not been determined. We evaluated drug concentrations among men who have sex with men in a substudy of the iPrEx trial (1). In this randomized placebo-controlled trial, daily oral doses of emtricitabine/tenofovir disoproxil fumarate were used as pre-exposure prophylaxis (PrEP) in men who have sex with men. Drug was detected less frequently in blood plasma and in viable cryopreserved peripheral blood mononuclear cells (PBMCs) in HIV-infected cases at the visit when HIV was first discovered compared with controls at the matched time point of the study (8% versus 44%; P < 0.001) and in the 90 days before that visit (11% versus 51%; P < 0.001). An intracellular concentration of the active form of tenofovir, tenofovir-diphosphate (TFV-DP), of 16 fmol per million PBMCs was associated with a 90% reduction in HIV acquisition relative to the placebo arm. Directly observed dosing in a separate study, the STRAND trial, yielded TFV-DP concentrations that, when analyzed according to the iPrEx model, corresponded to an HIV-1 risk reduction of 76% for two doses per week, 96% for four doses per week, and 99% for seven doses per week. Prophylactic benefits were observed over a range of doses and drug concentrations, suggesting ways to optimize PrEP regimens for this population.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866283847&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51846
ISSN: 19466242
19466234
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.