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Title: Bioactive carbazole alkaloids from Clausena wallichii roots
Authors: Wisanu Maneerat
Thunwadee Ritthiwigrom
Sarot Cheenpracha
Trinop Promgool
Kulsiri Yossathera
Suwanna Deachathai
Wong Phakhodee
Surat Laphookhieo
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 27-Apr-2012
Abstract: Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy.
ISSN: 15206025
Appears in Collections:CMUL: Journal Articles

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