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Title: Lack of CTGF*-945c/G dimorphism in Thai patients with systemic sclerosis
Authors: Worawit Louthrenoo
Nuntana Kasitanon
Ramjai Wichainun
Suparaporn Wangkaew
Waraporn Sukitawut
Yuka Ohnogi
Shoji Kuwata
Fujio Takeuchi
Keywords: Medicine
Issue Date: 10-Nov-2011
Abstract: An association between connective tissue growth factor (CTGF) gene dimorphism at -945 (CTGF*-945C/G) and systemic sclerosis (SSc) has been reported with inconclusive results. We performed this study to determine whether such an association exists among Thai patients with SSc. DNA samples were taken from 50 Thai SSc patients (diffuse SSc in 39 and limited SSc in 11) and 99 healthy controls for determination of CTGF*-945C/G dimorphism by polymerase chain reaction (PCR) using specific oligonucleotide primers. The associations between the genotype frequencies, clinical manifestations and auto-antibodies were determined as well. When compared with the controls, SSc patients had no significantly higher frequencies of the GG genotype (44.0% vs 39.4%, p = 0.60), G allele (63.0% vs 65.2%, p = 0.80) or G phenotype (82.0% vs 90.9%, p = 1.0). There was no association between the presence of the GG genotype and clinical manifestations (pulmonary fibrosis, sclerodactyly, digital pitting scars, telangiectasia and pulmonary arterial hypertension), or the presence of auto-antibodies (anti-Scl-70, anti-SSA/Ro, and anti-RNP). In conclusion, we found no association between CTGF*-945C/G dimorphism and Thai SSc patients. © Louthrenoo et al.
ISSN: 18743129
Appears in Collections:CMUL: Journal Articles

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