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dc.contributor.authorEkkasit Tharavichitkulen_US
dc.contributor.authorPooriwat Muangwongen_US
dc.contributor.authorSomvilai Chakrabandhuen_US
dc.contributor.authorPitchayaponne Klunklinen_US
dc.contributor.authorWimrak Onchanen_US
dc.contributor.authorBongkot Jia-Mahasapen_US
dc.contributor.authorWannapha Nobnopen_US
dc.contributor.authorDamrongsak Tippanyaen_US
dc.contributor.authorRazvan M. Galalaeen_US
dc.contributor.authorImjai Chitapanaruxen_US
dc.description.abstractPurpose: This study aimed to evaluate retrospectively the treatment results when using various image-guided adaptive brachytherapy treatments for cervical cancer treated by radical radiotherapy. Methods and Materials: From 2014 to 2017, 188 patients with cervical carcinoma were treated by whole pelvic radiotherapy plus four fractions of image-guided brachytherapy. Eight patients were excluded because of missing data. Consequently, 180 patients were analyzed. Of 180 patients, 92 were treated by CT-based brachytherapy (CT-BT), and transabdominal ultrasound–based brachytherapy (TAUS-BT) was used to treat another group. The treatment results and toxicity outcomes were evaluated by comparing the image-guidance techniques. Results: The mean follow-up time was 32 months (interquartile range 29.5–42 months). The mean age was 57 years (interquartile range from 50 to 65 years). In the CT-BT group, the mean cumulative doses to high-risk clinical target volume, bladder, rectum, and sigmoid were 87.2 Gy, 84.0 Gy, 68.8 Gy, and 69.8 Gy, respectively. In the TAUS-BT group, the mean cumulative doses to the cervix reference, bladder, and rectum points were 84.0 Gy, 65.5 Gy, and 74.0 Gy, respectively. There were no differences in the 2-year local control rate (p = 0.88) and disease-free survival rate (p = 0.34) in both groups. No difference in gastrointestinal and genitourinary toxicity was observed in both groups, but there was higher vaginal toxicity in the TAUS-BT group compared with the CT-BT group (p = 0.03). Conclusions: No difference in treatment results was observed between CT-based and TAUS-based approaches. However, TAUS-BT had higher vaginal toxicity in our retrospective analysis.en_US
dc.titleComparison of clinical outcomes achieved with image-guided adaptive brachytherapy for cervix cancer using CT or transabdominal ultrasounden_US
article.volume20en_US, Austriaen_USät zu Kielen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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