Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/77044
Title: Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy
Authors: Ehsan Razeghian
Ria Margiana
Supat Chupradit
Dmitry O. Bokov
Walid Kamal Abdelbasset
Faroogh Marofi
Siavash Shariatzadeh
Foad Tosan
Mostafa Jarahian
Authors: Ehsan Razeghian
Ria Margiana
Supat Chupradit
Dmitry O. Bokov
Walid Kamal Abdelbasset
Faroogh Marofi
Siavash Shariatzadeh
Foad Tosan
Mostafa Jarahian
Keywords: Medicine
Issue Date: 27-Aug-2021
Abstract: Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85114747651&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/77044
ISSN: 2296858X
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.