Comparison of the effect of tranexamic acid at various concentrations on the degradation time of platelet-rich fibrin

Abstract

This study aimed to compare platelet-rich fibrin (PRF) membranes obtained using a conventional method and those obtained using the tranexamic acid-mixed method at various concentrations in terms of appearance, weight, and degradation period. In this in vitro study, 20 PRF membranes were divided into four groups, including a conventional group manipulated using the conventional method. The remaining groups were prepared using tranexamic acid at concentrations of 50, 150, and 200 mg. The PRF membranes were evaluated for gross weight, degradation period, and daily remaining weight for 28 days. There were no statistically significant differences in gross weight among all the groups (p = 0.985). The 150 and 200 mg groups had a longer degradation period (more than 28 days), which was significantly longer than that of the control and 50 mg groups (p = 0.048). The daily remaining weights of the 150 and 200 mg groups were significantly greater than that of the control group observed from day 13 to the end of the experiment. The tranexamic acid-mixed technique had no effect on the appearance and weight of the PRF membranes. Moreover, the technique could delay their degradation.