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dc.contributor.authorPrangmalee Leurcharusmeeen_US
dc.contributor.authorPassakorn Sawaddiruken_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.description.abstractGarlic and its derivatives are widely recognized as herbal medications for the prevention and treatment of certain conditions associated with mitochondrial dysfunction, such as cardiovascular disease, neurological disease, diabetes, aging, and various cancers. Biological properties of garlic involve modulation of mitochondrial respiration, biogenesis and dynamics and regulation of apoptotic, oxidative stress, cell growth, cell proliferation, and inflammatory processes. Interestingly, garlic preparations and its bioactive compounds can both enhance and impair mitochondrial function depending on basal cellular function. Garlic impairs mitochondrial function leading to oxidative stress, apoptosis cell, and cycle arrest in normal and cancer cells, whereas it improves mitochondrial function resulting in antioxidant, antiapoptotic, and antiinflammatory activities in stress-induced conditions. In summary, garlic and its bioactive compounds exert protective effects against stress-induced conditions and exhibit anticancer activity in several cancer cell types.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titlePossible roles of garlic and its bioactive components on mitochondrial function in physiological and pathological conditionsen_US
article.title.sourcetitleMitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Healthen_US of Medicine, Chiang Mai Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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