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dc.contributor.authorAnuluck Junkumen_US
dc.contributor.authorWanchai Maleewongen_US
dc.contributor.authorAtiporn Saeungen_US
dc.contributor.authorDanita Champakaewen_US
dc.contributor.authorArpaporn Chansangen_US
dc.contributor.authorDoungporn Amornlerdpisonen_US
dc.contributor.authorArunee Kongdee Aldreden_US
dc.contributor.authorUdom Chaithongen_US
dc.contributor.authorAtchariya Jitpakdien_US
dc.contributor.authorDoungrat Riyongen_US
dc.contributor.authorBenjawan Pitasawaten_US
dc.description.abstractLigusticum sinense Oliv. cv. is a species of Umbelliferae (Apiaceae), a large plant family in the order Apiales. In this study, L. sinense hexane extract nanoemulsion gel (LHE-NEG) was investigated for mosquito repellency and compared to the standard chemical, N,N-diethyl-3-methylbenzamide (DEET), with the goal of developing a natural alternative to synthetic repellents in protecting against mosquito vectors. The results demonstrated that LHE-NEG afforded remarkable repellency against Aedes aegypti, Anopheles minimus, and Culex quinquefasciatus, with median protection times (MPTs) of 5.5 (4.5–6.0), 11.5 (8.5–12.5), and 11.25 (8.5–12.5) h, respectively, which was comparable to those of DEET-nanoemulsion gel (DEET-NEG: 8.5 (7.0–9.0), 12.0 (10.0–12.5), and 12.5 (10.0–13.5) h, re-spectively). Evaluation of skin irritation in 30 human volunteers revealed no potential irritant from LHE-NEG. The physical and biological stability of LHE-NEG were determined after being kept under heating/cooling cycle conditions. The stored samples of LHE-NEG exhibited some changes in appearance and differing degrees of repellency between those kept for 3 and 6 heating/cooling cycles, thus providing slightly shorter MPTs of 4.25 (4.0–4.5) and 3.25 (2.5–3.5) h, respectively, when compared to those of 5.0 (4.5–6.0) h in fresh preparation. These findings encourage commercially developed LHE-based products as an alternative to conventional synthetic repellents in preventing mosquito bites and helping to interrupt mosquito-borne disease transmission.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleLigusticum sinense nanoemulsion gel as potential repellent against aedes aegypti, anopheles minimus, and culex quinquefasciatus (Diptera: Culicidae)en_US
article.volume12en_US Universityen_US of Medicine, Khon Kaen Universityen_US Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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